Research

anti-FAP iBodies

We are currently working on development of iBodies® directed towards FAP

FIBROBLAST ACTIVATION PROTEIN is a membrane-bound serine protease, which is highly over-expressed in stromal fibroblasts of up to 90% of epithelial tumors, while showing minimal expression levels in healthy tissues. Proteases play an important role in tumor progression via promoting the cancerous ce continue reading...

anti-CA IX iBody

We are currently working on development of iBodies® directed towards CA IX

CARBONIC ANHYDRASE IX belongs to a group of carbonic anhydrases; enzymes which are a part of the metalloprotease family. These proteases catalyze a basic physiological reaction in which CO2 is converted to bicarbonate ion and protons. Besides that, CAs are involved in many other physiological as wel continue reading...

anti-NAs iBody

We are currently working on development of iBodies® directed towards viral NAs

VIRAL NEURAMINIDASES are exosialidases on the surface of the influenza virus that promote the release of the progeny viruses from the host cell and thus their spread through the organism. Inhibition of viral neuraminidases represents promising means for treatment of influenza via preventing the spre continue reading...

iBodies against Different Protease Families

We are currently working on development of iBodies® directed towards whole protease families

PROTEASES are enzymes that accelerate the hydrolysis of peptide bonds. iBodies® accessorized with inhibitors specific to whole families of these enzymes are under development. Currently, two of the main protease groups; aspartic and serine proteases are being explored. ASPARTIC PROTEASE FAMILY Tar continue reading...