We are currently working on development of iBodies® directed towards CA IX
CARBONIC ANHYDRASE IX belongs to a group of carbonic anhydrases; enzymes which are a part of the metalloprotease family. These proteases catalyze a basic physiological reaction in which CO2 is converted to bicarbonate ion and protons. Besides that, CAs are involved in many other physiological as well as pathological processes. CA IX is a tumor-associated isoform of the enzyme whose expression is highly upregulated in many types of tumors through the hypoxia inducible factor 1 (HIF1) cascade. CA IX represents a promising target for cancer diagnosis and therapy.